Direct measurement of myocardial viability by manganese-enhanced MRI (MEMRI) tracks the regenerative effects by human pluripotent stem cell derived cardiomyocytes (hPCMs)
نویسندگان
چکیده
Background Human pluripotent stem cell derived cardiomyocytes (hPCMs) may regenerate the myocardium to restore the cardiac function. Manganese-enhanced MRI (MEMRI) enters the cardiomyocytes via calcium channel to generate viability signal directly. Persistent engraftment of the hPCMs associated with increased myocardial viability and LVEF suggests regeneration. This study tests the hypothesis that hPCMs regenerate the injured murine myocardium.
منابع مشابه
In vivo multi-modality tracking of the regenerative effects of the human induced pluripotent stem cell-derived cardiomyocytes (iCMs)
Background In vivo multi-modality cellular and molecular imaging of the engrafted iCMs is necessary to characterize the engraftment and the regional effects on the viability of the injured myocardium. Zinc finger nuclease (ZFN)mediated integration of the reporter gene into the AAVS1 locus in the iCMs and manganese enhanced MRI (MEMRI) should allow precise in vivo detection of myocardial regener...
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